Sterically Demanding Flexible Phosphoric Acids for Constructing Efficient and Multi‐Purpose Asymmetric Organocatalysts

Abstract Herein, we present a novel approach for various asymmetric transformations of cyclic enones. The combination readily accessible chiral diamines and sterically demanding flexible phosphoric acids resulted in simple highly tunable catalyst framework. careful optimization the components led to identification particularly powerful multi‐purpose organocatalyst, which was successfully applied epoxidations, aziridinations, aza‐Michael‐initiated cyclizations, as well Robinson‐like Michael‐initiated ring closure/aldol cyclization. High catalytic activities excellent stereocontrol observed all four reaction types, indicating versatility our system. Furthermore, change diamine's configuration provided easy access both product antipodes cases.